Institute for Plant Genomics & Biotechnology

EDUCATION AND TRAINING

University of Novi Sad (Serbia)        Food Engineering                        B.S. 1977
Iowa State University                          Chemical Engineering                M.S. 1983
Iowa State University                          Chemical    Engineering            Ph.D. 1986

PROFESSIONAL EXPERIENCE

2012-present      Associate Director, National Center for Therapeutic Manufacturing, Texas A&M University
2006-present      Director of Bioseparations Lab, Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX
2003-present      Dow Professor in Bioprocess Engineering, Texas A&M University, College Station, TX
2001-2003           Vice President, ProdiGene Inc., College Station, TX
1999-2001            Director, ProdiGene Inc., College Station, TX
1998-1999            Professor, Iowa State University, Ames, IA
1993-1998           Associate Professor, Iowa State University, Ames, IA
1987-1993           Assistant Professor, Iowa State University, Ames, IA

RESEARCH INTERESTS

Recovery and purification of recombinant biomolecules from transgenic systems; bioprocessing of microalgae for biofuels and bioproducts; process design and economics.

HONORS AND AWARDS

2003    Dow Professor in Bioprocess Engineering, Texas A&M University, College Station, TX
2012     BAEN Excellence in Teaching Award

PROFESSIONAL ACTIVITIES

2014 –          Editorial Board Member, Journal of Biotechnology and Bioengineering
2014             NSF/SBIR Panel, Biomedical Devices
2012             Scientific Board Member of the 6th Central European Congress on Food, Serbia
2010             NSF Panel, Metabolic Engineering and Biofuels
2006-10      Scientific Advisory Board, ERA Biotech, Spain
2005-07     Editorial Board Member, Brazilian Journal of Chemical Engineering
2005-07     Scientific Advisory Board, InB: Biotechnologies Inc.
2007-          Scientific Advisory Board, Infinite Enzymes, Inc.
2007-          Editorial Board, Journal of Biological Engineering
2006            USDA/NRI Panel
2004            Visiting Professor, School of Chemical Engineering, University of Campinas, Brazil
2005           USDA/NRI Panel
2003          NIH-NIAID Panel, Regional Centers of Excellence in Biodefense and Emerging Diseases.
2003          NIH-NIAID Panel, Cooperative Research for the Development of Vaccines, Adjuvants, Therapeutics and Diagnostics
2002          NIH-NIAID Special Emphasis Panel, Partnership for Novel Therapeutic, Diagnostic and Vector Control Strategies
1999          NSF/EPA Panel, Technology for a Sustainable Environment

SELECTED PEER REVIEWED PUBLICATIONS

1. Munjal, N., Garzon-Sanabria, A. J., Quinones, K., Gregory, J., Nikolov, Z. L., 2014. Light-induced production of an antibody fragment and malaria vaccine antigen from Chlamydomonas reinhardtii. Processes 2: 625-638.
2. Garzon-Sanabria, A. J., Ramirez-Caballero, S.S., Moss, F., Nikolov, Z. L., 2013. Effect of algogenic organic matter (AOM) and sodium chloride on Nannochloropsis salina flocculation efficiency, Bioresource Technology, 143: 231-237.
3. Barros G.O.F, Ballen, M.A.T., Woodard S. L., Wilken, L. R., White, S. G., Damaj, M. B., Mirkov, T. E., and Nikolov Z. L. 2013. Recovery of bovine lysozyme from transgenic sugarcane stalks. Bioprocess Biosystems. Eng. 36: 1407-1416.
4. Egelkrout, E., McGaughey, K., Keener, T., Ferleman, A., Woodard, S., Devaiah, S. Nikolov, Z. L, Hood. E. and Howard, J. 2013. Enhanced Expression Levels of Cellulase Enzymes Using Multiple Transcription Units. Bioenerg. Res. 6: 699-710.
5. Wilken, L.R. and Z.L. Nikolov. 2012. Recovery and purification of plant-made foreign proteins. Biotechnol. Advances 30: 419-43.
6. Garzon-Sanabria A. J, Davis, R., Nikolov, Z. L. 2012. Harvesting Nannochloris oculata by inorganic flocculation. Bioresource Technol., 118: 418-424.
7. Barros G.O.F, Woodard S.L., Nikolov Z. L. 2011. Phenolics removal from transgenic Lemna minor extracts expressing mAb and impact on mAb production cost. Biotechnol. Progr. 27: 410-418.
8. Wilken, L.R. and Z.L. Nikolov. 2011. Process evaluation and economic analyses of recombinant human lysozyme and hen egg-white lysozyme purifications. Biotechnol. Progr. 27: 733-743.
9. Woodard, S.L., Wilken, L.R., Barros, G.O.F., White, S.G., & Nikolov, Z. L. 2009. Evaluation of Monoclonal Antibody and Phenolic Extraction from Transgenic Lemna for Purification Process Development. Biotechnol. Bioeng.104: 562-571.
10. Wilken, L.R. and Nikolov, Z. L. 2010. Evaluation of Alternatives for Human Lysozyme Purification from Transgenic Rice: Impact of Phytic Acid and Buffer. Biotechnol. Prog. 26: 1303-1311.
11. Zhu, L.; van de Lavoir, M. C.; Albanese J.; Beenhouwer, D. O.; Cardarelli, P.M.; Deng, D. F.; Deshpande S.; Diamond, J. H.; Green, L; Nikolov, Z. L. et al. 2005. Production of human monoclonal antibodies in eggs of chimeric chickens. Nat. Biotechnol., 23: 1159-1169.
12. Nandi, S, Yalda, E, Lu. S., Nikolov. Z. L, Misaki, R., Kazuhito, F, Huang N. 2005. Process development and economic evaluation of recombinant human lactoferrin expressed in rice grain. Transgenic Res., 14:237-249
13. Nikolov, Z. L.and S. Woodard. 2004. Downstream processing of recombinant proteins from transgenic feedstock, Curr Opin Biotechnol.,15: 479-486.